Cables1 rabbit pAb

• Background :

  This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127) .Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

• Description :

  This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

• UniProt :

  Q8TDN4

• Swiss Prot :

  Q8TDN4

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human Ik3-1. AA range:561-610

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  67kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  67kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity) . .

• Other Product Names :

  CABLES1; CABLES; CDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1

• Gene ID (Human) :

  91768