Frizzled-7 rabbit pAb

• Background :

  Frizzled class receptor 7 (FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

• Description :

  Frizzled class receptor 7 (FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],

• UniProt :

  O75084

• Swiss Prot :

  O75084

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; Flow Cyt; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; Flow Cyt 1:50-200; IF/ICC 1:100-500; ELISA 1:5000-20000

• Molecular Weight :

  64kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  64kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) . Localized in recycling endosomes in other conditions. .

• Other Product Names :

  FZD7; Frizzled-7; Fz-7; hFz7; FzE3

• Gene ID (Human) :

  8324