FRS2 rabbit pAb

• Background :

  Function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1., PTM:Phosphorylated on tyrosine residues upon stimulation by NGF., PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination., sequence caution:Translated as stop., similarity:Contains 1 IRS-type PTB domain., subcellular location:Cytoplasmic, membrane-bound., subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity) . Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11., tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

• Description :

  Function: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. PTM: Phosphorylated on tyrosine residues upon stimulation by NGF. PTM: Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. sequence Caution: Translated as stop. similarity: Contains 1 IRS-type PTB domain. subcellular location: Cytoplasmic, membrane-bound. subunit: Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. tissue specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

• Product Name Alternative :

  FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1

• UniProt :

  Q8WU20

• Swiss Prot :

  Q8WU20

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human FRS2. AA range:162-211

• Target :

  FRS2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  65kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  65kD

• Fragment :

  IgG

• Subcellular Location :

  Endomembrane system. Cytoplasmic, membrane-bound.

• Other Product Names :

  FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1

• Gene ID (Human) :

  10818