MAChR M4 rabbit pAb

• Background :

  The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

• Description :

  The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008],

• Product Name Alternative :

  CHRM4; Muscarinic acetylcholine receptor M4

• UniProt :

  P08173

• Swiss Prot :

  P08173

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human CHRM4. AA range:236-285

• Target :

  MAChR M4

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  53kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  53kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

• Other Product Names :

  CHRM4; Muscarinic acetylcholine receptor M4

• Gene ID (Human) :

  1132