Plakophilin 2 rabbit pAb

• Background :

  This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

• Description :

  This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008],

• Product Name Alternative :

  PKP2; Plakophilin-2

• UniProt :

  Q99959

• Swiss Prot :

  Q99959

• Reactivity :

  Human; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human PKP2. AA range:632-681

• Target :

  Plakophilin 2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  97kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  97kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cell junction, desmosome . Nuclear and associated with desmosomes.

• Other Product Names :

  PKP2; Plakophilin-2

• Gene ID (Human) :

  5318