SnoN rabbit pAb

• Background :

  The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB) . In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Description :

  The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• UniProt :

  P12757

• Swiss Prot :

  P12757

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  77kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  77kD

• Fragment :

  IgG

• Subcellular Location :

  Acrosomal vesicle, nucleus, nucleoplasm, transcription factor complex, cytoplasm, PML body, transcriptional repressor complex, protein complex

• Other Product Names :

  SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein

• Gene ID (Human) :

  6498