UBE3C rabbit pAb

• Background :

  Function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo., miscellaneous:A cysteine residue is required for ubiquitin-thioester formation., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain., similarity:Contains 1 IQ domain., subunit:Interacts with 26S proteasomes. Binds CAND2., tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.

• Description :

  Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. miscellaneous: A cysteine residue is required for ubiquitin-thioester formation. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. similarity: Contains 1 IQ domain. subunit: Interacts with 26S proteasomes. Binds CAND2. tissue specificity: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.

• Product Name Alternative :

  UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2

• UniProt :

  Q15386

• Swiss Prot :

  Q15386

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from the Internal region of human UBE3C.

• Target :

  UBE3C

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  125kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  125kD

• Fragment :

  IgG

• Subcellular Location :

  Proteasome complex, intracellular, nucleus, cytoplasm

• Other Product Names :

  UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2

• Gene ID (Human) :

  148581