Rab 5A rabbit pAb

• Background :

  Enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP., function:Required for the fusion of plasma membranes and early endosomes., similarity:Belongs to the small GTPase superfamily. Rab family., subcellular location:Enriched in stage I melanosomes., subunit:Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, UNC84B, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3.

• Description :

  Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. function: Required for the fusion of plasma membranes and early endosomes. similarity: Belongs to the small GTPase superfamily. Rab family. subcellular location: Enriched in stage I melanosomes. subunit: Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, UNC84B, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3.

• Product Name Alternative :

  RAB5A; RAB5; Ras-related protein Rab-5A

• UniProt :

  P20339

• Swiss Prot :

  P20339

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from the Internal region of human RAB5A. AA range:71-120

• Target :

  Rab 5A

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  24kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  24kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome membrane ; Lipid-anchor . Melanosome . Cytoplasmic vesicle . Cell projection, ruffle . Membrane . Cytoplasm, cytosol . Cytoplasmic vesicle, phagosome membrane . Endosome membrane . Enriched in stage I melanosomes (PubMed:17081065) . Alternates between membrane-bound and cytosolic forms (Probable) . .

• Other Product Names :

  RAB5A; RAB5; Ras-related protein Rab-5A

• Gene ID (Human) :

  5868