DNA pol δ3 rabbit pAb

• Background :

  This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA) . Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

• Description :

  This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012],

• Product Name Alternative :

  POLD3; KIAA0039; DNA polymerase delta subunit 3; DNA polymerase delta subunit p66

• UniProt :

  Q15054

• Swiss Prot :

  Q15054

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human POLD3. AA range:411-460

• Target :

  DNA pol δ3

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  51kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  51kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . Partially colocalizes with PCNA and POLD1 at S phase replication sites (PubMed:11595739) . Recruited to DNA damage sites within 2 hours following UV irradiation (PubMed:20227374, PubMed:22801543) . .

• Other Product Names :

  POLD3; KIAA0039; DNA polymerase delta subunit 3; DNA polymerase delta subunit p66

• Gene ID (Human) :

  10714