JAK3 rabbit pAb

• Background :

  The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease) . [provided by RefSeq, Jul 2008]

• Description :

  The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in Cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008],

• UniProt :

  P52333

• Swiss Prot :

  P52333

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human JAK3. AA range:751-800

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  125kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  125kD

• Fragment :

  IgG

• Subcellular Location :

  Endomembrane system ; Peripheral membrane protein . Cytoplasm .

• Other Product Names :

  JAK3; Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAK

• Gene ID (Human) :

  3718