Arkadia rabbit pAb

• Background :

  Ring finger protein 111 (RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

• Description :

  Ring finger protein 111 (RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

• Product Name Alternative :

  RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111

• UniProt :

  Q6ZNA4

• Swiss Prot :

  Q6ZNA4

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

• Target :

  Arkadia

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  110kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  110kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .

• Other Product Names :

  RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111

• Gene ID (Human) :

  54778