Bradykinin B1 R rabbit pAb

• Background :

  Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

• Description :

  Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],

• Product Name Alternative :

  BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor

• UniProt :

  P46663

• Swiss Prot :

  P46663

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human BDKRB1. AA range:201-250

• Target :

  Bradykinin B1 R

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  40kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  40kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane; Multi-pass membrane protein.

• Other Product Names :

  BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor

• Gene ID (Human) :

  623