Tuberin (phospho Thr1462) rabbit pAb

• Background :

  Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Description :

  Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

• UniProt :

  P49815

• Swiss Prot :

  P49815

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Thr1462. AA range:1428-1477

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight :

  200kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  200kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

• Other Product Names :

  TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein

• Gene ID (Human) :

  7249