AMBRA1 rabbit pAb

• Background :

  Function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation., similarity:Contains 3 WD repeats., subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.

• Description :

  Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. similarity: Contains 3 WD repeats. subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.

• Product Name Alternative :

  Autophagy/beclin-1 regulator 1

• UniProt :

  Q9C0C7

• Swiss Prot :

  Q9C0C7

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthetic Peptide of AMBRA1

• Target :

  AMBRA1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000, ELISA 1:10000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  140kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  140kD

• Fragment :

  IgG

• Subcellular Location :

  Endoplasmic reticulum . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome . Mitochondrion . Cytoplasm, cytosol . Nucleus . Cell junction, focal adhesion . Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139) . Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139) . Partially localizes at mitochondria in normal conditions (PubMed:21358617) . Localizes also to discrete punctae along the ciliary axoneme (By similarity) . .

• Other Product Names :

  Autophagy/beclin-1 regulator 1

• Gene ID (Human) :

  55626