RXRA rabbit pAb

• Background :

  Retinoid X receptor alpha (RXRA) Homo sapiens Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

• Description :

  Retinoid X receptor alpha (RXRA) Homo sapiens Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014],

• UniProt :

  P19793

• Swiss Prot :

  P19793

• Reactivity :

  Human; Mouse; Rat; Bovine

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 200-280

• Target :

  RXRA

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  50kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  50kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Mitochondrion . Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776) . Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331) . Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776) . Increased nuclear localization upon pulsatile shear stress (PubMed:28167758) . .

• Gene ID (Human) :

  6256