GBLP rabbit pAb

• Background :

  Domain:The WD repeats domain 5 mediates interaction with TRIM63., function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation., similarity:Belongs to the WD repeat G protein beta family., similarity:Contains 7 WD repeats., subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells., subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.

• Description :

  Domain: The WD repeats domain 5 mediates interaction with TRIM63. function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. similarity: Belongs to the WD repeat G protein beta family. similarity: Contains 7 WD repeats. subcellular location: Located on plasma membrane of neuroblastoma NMB7 cells. subunit: Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.

• UniProt :

  P63244

• Swiss Prot :

  P63244

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  GBLP

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  34kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  34kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Peripheral membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333) . Also associated with the membrane in oncogene-transformed cells (PubMed:11884618) . PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199) . In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity) . Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310) . .

• Gene ID (Human) :

  10399