PARP9 rabbit pAb

• Background :

  Catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., miscellaneous:Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration., similarity:Contains 1 PARP catalytic domain., similarity:Contains 2 Macro domains., subunit:Interacts with BBAP., tissue specificity:Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.

• Description :

  Catalytic activity: NAD (+) + (ADP-D-ribosyl) (n)-acceptor = nicotinamide + (ADP-D-ribosyl) (n+1)-acceptor. miscellaneous: Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. similarity: Contains 1 PARP catalytic domain. similarity: Contains 2 Macro domains. subunit: Interacts with BBAP. tissue specificity: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.

• UniProt :

  Q8IXQ6

• Swiss Prot :

  Q8IXQ6

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 450-530

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  93kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  93kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytosol . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:16809771) . Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788) . Export to the cytosol depends on the interaction with DTX3L (PubMed:16809771) . Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742) . .

• Gene ID (Human) :

  83666