SARM1 rabbit pAb

• Background :

  Caution:Was initially reported to contain ARM repeats (PubMed:11386760) . Such repeats are however not predicted by any detection method., function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation., similarity:Contains 1 TIR domain., similarity:Contains 2 SAM (sterile alpha motif) domains., subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function., tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

• Description :

  Caution: Was initially reported to contain ARM repeats (PubMed: 11386760). Such repeats are however not predicted by any detection method. function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. similarity: Contains 1 TIR domain. similarity: Contains 2 SAM (sterile alpha motif) domains. subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. tissue specificity: Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

• UniProt :

  Q6SZW1

• Swiss Prot :

  Q6SZW1

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 281-330

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  79kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  79kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Mitochondrion . Associated with microtubules. .

• Gene ID (Human) :

  23098