AGRP rabbit pAb

• Background :

  Disease:Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665]., domain:The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin., function:Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding., similarity:Contains 1 agouti domain., tissue specificity:Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

• Description :

  Disease: Defects in AGRP may be a cause of autosomal dominant obesity [MIM: 601665]. Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. function: Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding. similarity: Contains 1 agouti domain. tissue specificity: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

• UniProt :

  O00253

• Swiss Prot :

  O00253

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human AGRP AA range: 21-70

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Secreted . Golgi apparatus lumen .

• Other Product Names :

  Agouti-related protein

• Gene ID (Human) :

  181