GABA A Receptor α4 rabbit pAb

• Background :

  Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1) . Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]

• Description :

  Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene. [provided by RefSeq, Feb 2011],

• UniProt :

  P48169

• Swiss Prot :

  P48169

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthetic Peptide of GABA A Receptor α4 AA range: 149-199

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000, IHC 1:100-200

• Molecular Weight :

  62kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  62kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

• Other Product Names :

  GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA (A) receptor subunit alpha-4

• Gene ID (Human) :

  2557