PROC (light chain, Cleaved-Leu179) rabbit pAb

• Background :

  This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

• Description :

  This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. [provided by RefSeq, Dec 2009],

• UniProt :

  P04070

• Swiss Prot :

  P04070

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human PROC (light chain, Cleaved-Leu179)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight :

  17 45kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  17 45kD

• Fragment :

  IgG

• Subcellular Location :

  Secreted . Golgi apparatus . Endoplasmic reticulum .

• Other Product Names :

  Vitamin K-dependent protein C (EC 3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]

• Gene ID (Human) :

  5624