Myosin VI rabbit pAb

• Background :

  Myosin VI (MYO6) Homo sapiens This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

• Description :

  Myosin VI (MYO6) Homo sapiens This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],

• Product Name Alternative :

  MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6

• UniProt :

  Q9UM54

• Swiss Prot :

  Q9UM54

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from Myosin VI . at AA range: 40-120

• Target :

  Myosin VI

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/5000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  149kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  149kD

• Fragment :

  IgG

• Subcellular Location :

  Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Golgi apparatus . Nucleus . Cytoplasm, perinuclear region . Membrane, clathrin-coated pit . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, filopodium . Cell projection, ruffle membrane . Cell projection, microvillus . Cytoplasm, cytosol . Also present in endocyctic vesicles (PubMed:16507995) . Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995) . Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149) . Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127) . Colocalizes with OPTN at the Golgi complex and in vesicul

• Other Product Names :

  MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6

• Gene ID (Human) :

  4646