ITGA5 (heavy chain, Cleaved-Arg894) rabbit pAb

• Background :

  Function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.

• Description :

  Function: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. similarity: Belongs to the integrin alpha chain family. similarity: Contains 7 FG-GAP repeats. subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.

• UniProt :

  P08648

• Swiss Prot :

  P08648

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight :

  94 110kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  94 110kD

• Fragment :

  IgG

• Subcellular Location :

  Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .

• Other Product Names :

  Integrin alpha-5 (CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

• Gene ID (Human) :

  3678